Translational Nephrology · Biomarker Science

Dr. Kumar DigvijayTranslational Nephrology Researcher

International research footprint India · Italy · Denmark

Advancing biomarkers for earlier detection and monitoring of kidney injury and transplant dysfunction.

Currently: Translational nephrology researcher · Department of Critical Care Medicine, Medanta Hospital, Ranchi, India (ongoing study collaboration) · Research collaborator, International Renal Research Institute of Vicenza (IRRIV), Italy.

17Scholarly publications
11PubMed-indexed
14+Years in nephrology research
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Portrait photograph of Dr. Kumar Digvijay, translational nephrology researcher
Translational pathway

From kidney biology to clinically useful signals

Kidney transplantationAllograft injury & phenotyping
→
Extracellular vesiclesUrine & plasma EV signals
→
Biomarker integrationMultimarker interpretation
→
Regenerative nephrologyRepair biology & translation
Profile

Research profile

My work bridges clinical nephrology and translational biomarker science. I have experience in urinary and plasma extracellular-vesicle isolation, MACSPlex multiplex bead-based flow-cytometric phenotyping, prospective human cohorts, clinical biomarker studies, cell and tissue culture, regenerative medicine and multicentre research, with international experience across Italy, Denmark and India.

Portfolio

Research focus

Kidney transplantation

Renal allograft injury, donor/recipient phenotyping, rejection biology and multimarker monitoring strategies.

Transplantation

Extracellular vesicles

Urinary and plasma EV isolation, multiplex flow-cytometric phenotyping and translational interpretation.

EV biology

Translational biomarkers

Biomarker-validation frameworks, clinical-molecular data integration and precision phenotyping in kidney disease.

Biomarkers

CKD & precision medicine

Mechanism-informed phenotyping, evidence synthesis and clinically oriented precision kidney medicine.

CKD

AKI & critical care nephrology

AKI biomarkers, sepsis-associated kidney dysfunction and renal-support research.

AKI / CRRT

Regenerative nephrology

Cell and tissue culture, regenerative medicine concepts and kidney-repair biology within translational nephrology research.

Regeneration
Methods & technical capabilitiesExplore laboratory methods, clinical research and study-development experience

Extracellular vesicles

Urinary and plasma EV isolation, pre-analytical handling and translational phenotyping workflows.

EV workflows

Flow cytometry & MACSPlex

Multiplex bead-based EV phenotyping, flow-cytometric acquisition and interpretation in biomarker studies.

Flow cytometry

Cell & tissue culture

Hands-on cell and tissue culture experience supporting translational, regenerative and kidney-disease research.

Cell culture

Regenerative medicine / nephrology

Regenerative medicine approaches, kidney repair biology and translational framing of cell-based and tissue-level research.

Regenerative nephrology

Biomarker studies

Clinical biomarker framing, multimarker strategies, sample-linked phenotyping and interpretation.

Translational biomarkers

Clinical studies, cohorts & trial support

Prospective human studies, biospecimen-linked research, protocol/CRF development, multicentre coordination, data-quality review and trial-related study documentation.

Clinical research

Protocols & CRFs

Study protocols, case-report forms, research documentation and operational study planning.

Study design

Scientific synthesis

Evidence synthesis, manuscript development, translational project framing and publication-oriented reporting.

Scientific writing

Biospecimen workflows

Human urine and plasma sample handling, pre-analytical preparation and biomarker-oriented study workflows.

Human biospecimens
Trajectory

Research Experience

Research Collaborator (Affiliated Researcher) · Department of Critical Care Medicine, Medanta Hospital, Ranchi, India

Protocol and case-report-form (CRF) development, prospective data collection, data-quality review, and planned multicentre analysis and reporting.

Postdoctoral Fellow – Kidney Transplant Medicine · Aarhus University Hospital, Denmark

Longitudinal urinary and plasma extracellular-vesicle profiling in kidney-transplant recipients.

PhD Researcher – Medical Physiopathology · University of Turin, Italy

Renal functional reserve and urinary extracellular-vesicle phenotyping in living kidney donors.

International Renal Research Institute of Vicenza (IRRIV), Italy

Research Fellow, 2018. Research fellowship in critical-care nephrology.

Research Collaborator, 2018–Present. Ongoing joint work with Prof. Claudio Ronco on AKI biomarkers, continuous renal replacement therapy (CRRT), sepsis-associated kidney injury, and scientific publications.

Nephrology Research Fellow · Sir Ganga Ram Hospital, New Delhi, India

Kidney transplantation, donor-specific antibodies, biomarkers, regenerative medicine and clinical research.

Doctoral research

PhD thesis

PhD in Medical Physiopathology · University of Turin, Italy · 2022

University of Turin

Renal Function Reserve (RFR) in Living Donor Renal Transplantation (LDRT) and Phenotypic Characterization of Urinary Extracellular Vesicles (uEVs) Pre and Post Nephrectomy

Prospective living-donor study combining oral protein-load renal stress testing with pre-nephrectomy and day-7 post-nephrectomy urinary EV phenotyping.
University repository ↗
Key outcomes

Renal adaptation and urinary-EV phenotyping after living kidney donation

28 living kidney donors enrolled; renal stress testing showed a significant GFR response to protein load (p=0.0001) with reported RFR of 29.5 (4.2–100) mL/min/1.73 m².

Urinary EVs were profiled before nephrectomy and again 7 days later. Post-nephrectomy increases in progenitor-associated CD133 and CD24 signals were observed, supporting their investigation as candidate indicators of renal adaptation and regenerative responses rather than validated clinical biomarkers.
Published work

Selected publications

17 scholarly publications: 16 peer-reviewed articles and 1 book chapter, including 11 PubMed-indexed publications.

2026

Artificial Intelligence-Guided Extracellular Vesicle Platforms for Diagnosis and Treatment of Chronic Kidney Disease

Digvijay K, Birn H, Ronco C · Medicina 62(10):1878

View ↗
2026

Combined Biomarker Approach Using Extracellular Vesicles, Donor-Derived Cell-Free DNA, and Donor-Specific Antibodies for Monitoring Renal Allograft Function

Digvijay K, Birn H · Medicina 62(4):664 · PMID: 42075536

PubMed ↗
2023

PAX 2 Mutation in an Indian Family with Renal Coloboma Syndrome

Digvijay K et al. · Kidney and Dialysis 3(3):255–264

View ↗
2021

Outcomes of Kidney Transplantation in the Elderly Recipients

Bhargava V et al., including Digvijay K · Indian Journal of Nephrology 31(4):370–376 · PMID: 34584353

PubMed ↗
2019

TIMP-2 · IGFBP7 levels are associated with adverse outcomes in ICU patients with acute kidney injury

Xie Y et al., including Digvijay K · Kidney International 95(6):1486–1493 · PMID: 30982674

PubMed ↗
2019

International Survey on the Management of Acute Kidney Injury and Continuous Renal Replacement Therapies: Year 2018

Digvijay K, Neri M, Fan W, Ricci Z, Ronco C · Blood Purification · PMID: 30269144

PubMed ↗
Browse all 17 publications ↗Conference abstracts ↗
Current scholarly work

Manuscripts under consideration

Under review

From Dysbiosis to Precision Gut–Kidney Medicine: A Functional Phenotyping Framework for Chronic Kidney Disease

Perspective · Clinical Journal of the American Society of Nephrology (CJASN)
Submitted

Extracorporeal Therapeutic Monitoring: A Framework for Response-Guided Blood Purification

Perspective · Blood Purification
Under review

Polymer Composites for Selective Removal of Pharmaceuticals from Hospital Wastewater: Design Lessons from Extracorporeal Blood Purification Sorbents

Mini Review · Frontiers in Materials
Academic contribution

Editorial leadership & scientific service

Guest Editor · Medicina

Pathophysiological Mechanisms and Therapeutic Strategies in Kidney Diseases.

2026–Present

Guest Editor · Medicina

Kidney Transplantation Complications.

2024–2025

Ad hoc peer reviewer

Nephron, BMC Nephrology, Diagnostics, Cells, Paediatric Reports and related biomedical journals.

2019–Present

Editorial Manager

Current Medicine Research and Practice.

2020–Present

Scientific communication

Volunteer scientific communication coordinator, Nephro Critical Care Society, India.

2026–Present

Professional memberships

ISN · ASN · ISEV · Alliance for Regenerative Medicine.

Network
Consultation & collaboration

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